The research on phytoene, a carotenoid included in common foods, has shown promise thanks to studies from the Universities of Kent and Seville. This study demonstrates how the dietary ingredient phytoene increases the life of the nematode Caenorhabditis elegans and lessens the impact of some common issues associated with Alzheimer’s disease. This has offered hope for disease prevention and a healthier ageing process.

The lifespan-extending properties of phytoene

The research has revealed that the carotenoid phytoene increased the lifespan of Caenorhabditis elegans (a type of roundworm) by 10 to 18.6%. Phytoene is naturally found in food ingredients like tomatoes, carrots, apricots, and red peppers. The study focused on testing pure phytoene and extracts derived from microalgae, both of which showed significant benefits in greatly improving longevity.
This finding is important because Caenorhabditis elegans is a model organism frequently used in biomedical research. Its cellular mechanisms are similar to those of humans which makes it an excellent subject for ageing and disease studies.

Reducing alzheimer’s disease paralysis

It has also been discovered that phytoene lessens the paralysis caused on by Alzheimer’s. The study demonstrated a 30–40% reduction in the proteotoxic effects of amyloid plaques, which are linked to Alzheimer’s disease. The results offer an important advancement in the treatment of Alzheimer’s because these plaques usually cause neuron loss and paralysis in models of the illness.
While these are preliminary findings, the research team expressed optimism in determining the precise mechanisms behind phytoene’s protective benefits. This may open the door to new medications meant to slow the evolution of Alzheimer’s in people.

Role of phytoene in disease prevention

Because phytoene may have some health benefits, researchers have been examining it for a long time. Phytoene has been investigated for its ability to defend against UV radiation, in addition to its latest discoveries about ageing and Alzheimer’s disease. This carotenoid is found in many tissues, including the epidermis, and is well absorbed by the organism.
The team of researchers at the University of Seville is also investigating the application of phytoene in nutrition, cosmetics, and agriculture as part of a sustainable approach to health. According to their research, phytoene can majorly help lower the risk of ageing-related disorders. because of this reason, it has become a valuable and adaptable substance for potential future medical advancements.
The researchers are particularly interested in understanding the biological mechanisms that enable phytoene to improve longevity and protect against Alzheimer’s disease.
While more research is needed to confirm its effects in humans, phytoene’s promising role in prolonging life and combating neurodegenerative diseases like Alzheimer’s could lead to significant advances in disease prevention.